Click Here to Download this Blog Post – The Great Masquerader: Why One Glitch Can Cause 20 Different Symptoms
(Part 18)

By Dr. Nicholas L. DePace, M..D., F.A.C.C – Cardiologist specializing in autonomic dysfunction, Ehlers-Danlos syndrome and POTS.

If you have Ehlers-Danlos Syndrome (EDS) or Hypermobility Spectrum Disorder (HSD), your medical chart might look like an alphabet soup of diagnoses.

You might be seeing different specialists for:

• Fibromyalgia (chronic pain)
• POTS (Postural Orthostatic Tachycardia Syndrome)
• MCAS (Mast Cell Activation Syndrome – allergies and rashes)
• Anxiety & Panic Attacks
• IBS or Leaky Gut

It can feel like your body is falling apart in ten different ways at once. But what if these aren’t ten separate diseases? What if they are just ten different symptoms of one underlying problem?

The Root Cause: P&S Dysfunction

As we have discussed, the core issue in EDS/HSD is often a malfunction in the Parasympathetic and Sympathetic (P&S) nervous systems. When this “wiring” is faulty, it creates a domino effect that impacts almost every system in your body.

The biggest consequence of this glitch is Poor Perfusion.

• Translation: Your blood isn’t getting pumped efficiently to the top half of your body.

When your nerves don’t tighten your blood vessels correctly, gravity wins. Blood pools in your legs, leaving your brain, heart, and upper muscles starving for oxygen.

The Mystery of “Coat-Hanger Pain”

One of the most common complaints in EDS patients is a deep, aching pain that runs across the tops of the shoulders and up the back of the neck.

Doctors often call this “Coat-Hanger Pain” because the pain follows the shape of a clothes hanger.

• The Mistake: Many people think this is just “stress” or “bad posture.”
• The Reality: This is actually a sign of poor blood flow. Because your upper body isn’t getting enough blood, the muscles in your neck and shoulders essentially stiffen and cramp. It is your muscles crying out for oxygen.

The Brain’s “Panic Button” (Adrenalin Storms)

When your brain realizes it isn’t getting enough blood (poor cerebral perfusion), it goes into survival mode. It thinks you are in danger, so it slams the alarm button.

This triggers an “Adrenalin Storm.”

• Physically: You might feel sudden chest pressure, sweating, or a racing heart.
• Mentally: You feel a surge of Anxiety or a Panic Attack.

This isn’t necessarily “psychological” anxiety. It is a physiological attempt by your body to force more blood to the brain.

The Link to ADHD and Focus

This lack of blood flow can even explain cognitive struggles.

• Brain Fog: The brain is running on low battery.
• ADHD/OCD: Some researchers believe that the hyperactivity seen in conditions like ADHD (or even high-functioning Autism) might be the brain’s way of keeping itself stimulated to maintain blood flow. It is “revving the engine” to keep from stalling.

A New Way to Treat

This perspective changes everything about treatment. Instead of taking one pill for anxiety, one for pain, and one for digestion, the goal should be to treat the P&S Dysfunction first.

We have seen that when we fix the blood flow issues and calm the nervous system:

1. The “Coat-Hanger” pain fades because muscles get oxygen.
2. The “Anxiety” drops because the brain stops hitting the panic button.
3. The “Brain Fog” lifts.

The Golden Rule: Treat the wiring first. If symptoms still persist after the blood flow is fixed, then (and only then) do we treat the specific organs.

Where to Seek Expert Care?

It is important to seek out a clinician with expertise in EDS to make an accurate diagnosis and create a treatment plan. One of the nation’s leading centers is Franklin Cardiovascular Associates, under the direction of Nicholas DePace, MD, FACC. They are located in Sicklerville, New Jersey. franklincardiovascular.com, (856) 589-6034

About the Author

Nicholas L. DePace, MD, FACC is a board-certified cardiologist and Medical Director of Franklin Cardiovascular Associates. A graduate of the Mount Sinai School of Medicine, Dr. DePace has decades of clinical, academic, and research experience and has held faculty appointments as a Clinical Professor of Medicine, becoming one of the youngest full professors in Philadelphia at the time of his appointment.

Dr. DePace specializes in the diagnosis and treatment of autonomic nervous system dysfunction (dysautonomia), including POTS, autonomic dysfunction associated with Ehlers-Danlos syndrome (EDS), chronic fatigue, and anxiety-like conditions that are frequently misdiagnosed. He is nationally recognized for his work on parasympathetic and sympathetic (P&S) nervous system imbalance, a core mechanism underlying many complex chronic disorders.

In addition to treating patients from across the United States, Dr. DePace is a prolific clinical researcher and author of multiple nationally distributed medical textbooks published by Springer and W.W. Norton, focusing on autonomic dysfunction, mitochondrial disorders, cardiovascular disease, and mind–body medicine.

👉 View Dr. DePace’s professional profile
👉 View medical books by Dr. DePace

Click Here to Download this Blog Post – The 24-Doctor Mystery: A Case Study of “Hidden” hEDS (Part 17)

By Dr. Nicholas L. DePace, M..D., F.A.C.C – Cardiologist specializing in autonomic dysfunction, Ehlers-Danlos syndrome and POTS.

Does this story sound familiar to you?

A 48-year-old woman walks into a doctor’s office. She isn’t there for a check-up; she is there because she is desperate. She has seen over two dozen doctors in her life—neurologists, heart specialists, rheumatologists—and yet, she still feels terrible.

She has been told she has “Generalized Anxiety.” She has been told she has “Fibromyalgia.” She has been told it is all in her head.

But she knows it isn’t. This is the story of how she finally found the answer.

The History: “Growing Pains” That Never Stopped

Looking back, the clues were there since childhood.

• School: She was a cheerleader and gymnast (a common history for hypermobile people because they are naturally flexible), but she was always exhausted. She was even home-schooled for a year because she was too tired to go to class.
• Work: She had to stop working full-time because of chronic “body aches” and brain fog.
• Daily Life: She was clumsy. Her ankles sprained easily. Her jaw clicked (TMJ). She bruised if you barely touched her. She had trouble sleeping and constantly felt “anxious.”

The Tipping Point

She managed to survive like this for years until she caught a mild case of COVID-19. Afterward, her body seemingly crashed.

Suddenly, her heart would race, and she felt dizzy every time she stood up. The brain fog became unbearable. The “auto-pilot” glitch we discussed earlier (Orthostatic Intolerance) had gone into overdrive.

The Examination: Finding the Clues

When she finally saw a doctor who understood connective tissue disorders, they didn’t just listen to her heart; they looked at the physical evidence that 24 other doctors had missed.

1. The “Party Tricks” (Beighton Score) The doctor tested her flexibility using the Beighton Score.

• Could she bend her pinky finger back past 90 degrees?
• Could she touch her thumb to her forearm?
• Did her knees and elbows bend backward?
• Could she touch the floor with her palms flat? She could when she was younger, but her back was stiffer now.

2. The “Heel Bumps” The doctor looked at her heels and found small, skin-colored bumps called Piezogenic Papules.

• What are they? Because her tissue is weak, small bits of fat push through the skin layers when she puts weight on her heels. It is a classic sign of EDS.

3. The Wrist Test The doctor asked her to wrap her thumb and pinky around her other wrist. Because she had long, slender fingers (a trait called arachnodactyly), her pinky overlapped her thumb easily.
4. The Vital Signs When she stood up, her heart rate jumped from 92 to 120 beats per minute. Her blood pressure dropped. This confirmed her autonomic nervous system was struggling to fight gravity.

The Diagnosis: Tears of Relief

The doctor put it all together: The flexibility, the skin signs, the dizziness, the fatigue, and the history of joint pain.

She met the criteria for Hypermobile Ehlers-Danlos Syndrome (hEDS).

When the doctor explained that she wasn’t “crazy,” that her anxiety was a physical reaction to a struggling nervous system, and that there was a name for her pain, she began to cry. She finally felt vindicated.

The Lesson

This patient suffered for decades because specialists have “tunnel vision.” The cardiologist looked only at the heart; the neurologist looked only at the nerves.

Connective tissue disorders require a “wide lens.” If you see yourself in this woman’s story—if you are the “anxious” patient who is flexible, tired, and hurting—it might be time to stop asking “What is wrong with my heart?” and start asking “What is wrong with my wiring?”

Where to Seek Expert Care?

It is important to seek out a clinician with expertise in EDS to make an accurate diagnosis and create a treatment plan. One of the nation’s leading centers is Franklin Cardiovascular Associates, under the direction of Nicholas DePace, MD, FACC. They are located in Sicklerville, New Jersey. franklincardiovascular.com, (856) 589-6034

About the Author

Nicholas L. DePace, MD, FACC is a board-certified cardiologist and Medical Director of Franklin Cardiovascular Associates. A graduate of the Mount Sinai School of Medicine, Dr. DePace has decades of clinical, academic, and research experience and has held faculty appointments as a Clinical Professor of Medicine, becoming one of the youngest full professors in Philadelphia at the time of his appointment.

Dr. DePace specializes in the diagnosis and treatment of autonomic nervous system dysfunction (dysautonomia), including POTS, autonomic dysfunction associated with Ehlers-Danlos syndrome (EDS), chronic fatigue, and anxiety-like conditions that are frequently misdiagnosed. He is nationally recognized for his work on parasympathetic and sympathetic (P&S) nervous system imbalance, a core mechanism underlying many complex chronic disorders.

In addition to treating patients from across the United States, Dr. DePace is a prolific clinical researcher and author of multiple nationally distributed medical textbooks published by Springer and W.W. Norton, focusing on autonomic dysfunction, mitochondrial disorders, cardiovascular disease, and mind–body medicine.

👉 View Dr. DePace’s professional profile
👉 View medical books by Dr. DePace

Click Here to Download this Blog Post – Ancient History, Modern Mystery: What Exactly IS Ehlers-Danlos Syndrome? (Part 16)

By Dr. Nicholas L. DePace, M..D., F.A.C.C – Cardiologist specializing in autonomic dysfunction, Ehlers-Danlos syndrome and POTS.

If you have Ehlers-Danlos Syndrome (EDS), you might feel like a medical mystery. But believe it or not, doctors have known about “excess mobility” since the days of Hippocrates in 400 BC.

The condition was officially named around 1900 by two dermatologists, Dr. Ehlers and Dr. Danlos. However, it was largely forgotten by modern medicine until 1960, when a doctor at Johns Hopkins brought it back into the spotlight.

Today, we know much more. Here is the breakdown of what is actually happening in your body and why it feels like so many people are suddenly talking about it.

The “Soft Skeleton”: What Goes Wrong?

The common denominator in all EDS and HSD (Hypermobility Spectrum Disorder) cases is Collagen.

Think of collagen as the “glue” that holds your body together. It is the main ingredient in your skin, muscles, ligaments, blood vessels, and heart valves. Experts call it the body’s “soft skeleton.” It supports everything that has shape.

In EDS/HSD patients, this glue is faulty. It’s too stretchy or too fragile. Because this glue is everywhere, the symptoms are everywhere—from loose joints to fragile skin.

Is It Actually Rare?

If you read a medical textbook, it might say EDS is “rare,” affecting about 1 in 5,000 people. Clinical experience suggests otherwise.

When you combine hEDS (the hypermobile type) with HSD (Hypermobility Spectrum Disorder), experts estimate the number is actually closer to 1 in 100 or 1 in 200 people. It is likely not “rare”—just rarely diagnosed correctly.

How Do Doctors Spot It?

To diagnose you, doctors often use a physical test called the Beighton Score. This checks how flexible you are.

• The Score: A score of 5 out of 9 usually indicates generalized hypermobility.
• The Age Factor: If you are older, you might not score as high because joints naturally stiffen with age. A good doctor knows this and looks at your history, not just your current flexibility.

Beyond flexibility, they look for:

• Tissue Fragility: Do you bruise like a peach? Do you scar easily or “weirdly”?
• Joint Issues: Do you have chronic pain or joints that partially pop out (subluxation)?

The “Red Flag”: Vascular EDS

While there are 13 types of EDS, one requires special attention: Vascular EDS (vEDS).

This type is rare and dangerous because it affects the blood vessels and organs, leading to a shorter life expectancy. It is crucial for doctors to rule this out, especially if you have a family history of vascular events (like aneurysms) before age 50.

Note: Doctors also need to rule out other similar conditions, like Marfan Syndrome or autoimmune diseases like Lupus, to make sure they have the right diagnosis.

“But Nobody Else in My Family Has It…”

This is a common confusion. While hEDS is often passed down from parent to child (what doctors call “autosomal dominant”), you don’t need a family history to have it.

About 50% of patients have a “de novo” mutation. This simply means the genetic change started with you. You didn’t inherit it, but you could pass it on.

Where to Seek Expert Care?

It is important to seek out a clinician with expertise in EDS to make an accurate diagnosis and create a treatment plan. One of the nation’s leading centers is Franklin Cardiovascular Associates, under the direction of Nicholas DePace, MD, FACC. They are located in Sicklerville, New Jersey. franklincardiovascular.com, (856) 589-6034

About the Author

Nicholas L. DePace, MD, FACC is a board-certified cardiologist and Medical Director of Franklin Cardiovascular Associates. A graduate of the Mount Sinai School of Medicine, Dr. DePace has decades of clinical, academic, and research experience and has held faculty appointments as a Clinical Professor of Medicine, becoming one of the youngest full professors in Philadelphia at the time of his appointment.

Dr. DePace specializes in the diagnosis and treatment of autonomic nervous system dysfunction (dysautonomia), including POTS, autonomic dysfunction associated with Ehlers-Danlos syndrome (EDS), chronic fatigue, and anxiety-like conditions that are frequently misdiagnosed. He is nationally recognized for his work on parasympathetic and sympathetic (P&S) nervous system imbalance, a core mechanism underlying many complex chronic disorders.

In addition to treating patients from across the United States, Dr. DePace is a prolific clinical researcher and author of multiple nationally distributed medical textbooks published by Springer and W.W. Norton, focusing on autonomic dysfunction, mitochondrial disorders, cardiovascular disease, and mind–body medicine.

👉 View Dr. DePace’s professional profile
👉 View medical books by Dr. DePace

Click Here to Download this Blog Post – The Long Road to Answers: Why You Were Misdiagnosed for Years (Part 15)

By Dr. Nicholas L. DePace, M..D., F.A.C.C – Cardiologist specializing in autonomic dysfunction, Ehlers-Danlos syndrome and POTS.

If you are reading this and finally have a diagnosis of hEDS or HSD, you might feel a mix of relief and anger.

For many patients, the diagnosis comes decades too late. You may have struggled through grade school, high school, and your career feeling like you were fighting a losing battle against your own body. You dealt with pain, extreme fatigue, brain fog, and joints that slipped out of place (subluxations)—all while being told you were “fine.”

The “It’s All in Your Head” Trap

The most common story in the EDS community is the patient who sees a dozen different doctors and is eventually labeled with “Anxiety” or a “Functional Disorder.”

Why does this happen? It’s not necessarily because the doctors are bad; it’s because the disease is a master of disguise.

The “Too Many Symptoms” Problem Medicine is often divided into specialties. You see a urologist for bladder issues, a gastroenterologist for stomach pain, a neurologist for headaches, and an optometrist for eye trouble.

• The eye doctor looks at your eyes and sees nothing wrong structurally.
• The stomach doctor does a scope and sees nothing wrong structurally.

Because these doctors often don’t talk to each other, nobody sees the big picture. They see a patient with a laundry list of complaints that don’t seem connected. When a doctor can’t find a physical cause for so many different problems, they often conclude the problem must be psychiatric.

Connecting the Dots

The reality is that these “unrelated” symptoms are actually all the same problem. Your connective tissue is everywhere—in your eyes, your gut, your bladder, and your nerves. When the tissue is faulty, everything malfunctions.

The Chicken or the Egg?

It is true that many hEDS/HSD patients suffer from anxiety and depression. However, it is crucial to understand the order of events:

• The Misconception: You are in pain and tired because you are anxious or depressed.
• The Reality: You are anxious and depressed because you are in chronic pain, your body is unreliable, and you haven’t been believed for years.

The mental health struggles are secondary. They are a natural human reaction to living with a debilitating, undiagnosed illness. You aren’t crazy—you’ve just been trying to survive without the right manual for your body.

Where to Seek Expert Care?

It is important to seek out a clinician with expertise in EDS to make an accurate diagnosis and create a treatment plan. One of the nation’s leading centers is Franklin Cardiovascular Associates, under the direction of Nicholas DePace, MD, FACC. They are located in Sicklerville, New Jersey. franklincardiovascular.com, (856) 589-6034

About the Author

Nicholas L. DePace, MD, FACC is a board-certified cardiologist and Medical Director of Franklin Cardiovascular Associates. A graduate of the Mount Sinai School of Medicine, Dr. DePace has decades of clinical, academic, and research experience and has held faculty appointments as a Clinical Professor of Medicine, becoming one of the youngest full professors in Philadelphia at the time of his appointment.

Dr. DePace specializes in the diagnosis and treatment of autonomic nervous system dysfunction (dysautonomia), including POTS, autonomic dysfunction associated with Ehlers-Danlos syndrome (EDS), chronic fatigue, and anxiety-like conditions that are frequently misdiagnosed. He is nationally recognized for his work on parasympathetic and sympathetic (P&S) nervous system imbalance, a core mechanism underlying many complex chronic disorders.

In addition to treating patients from across the United States, Dr. DePace is a prolific clinical researcher and author of multiple nationally distributed medical textbooks published by Springer and W.W. Norton, focusing on autonomic dysfunction, mitochondrial disorders, cardiovascular disease, and mind–body medicine.

👉 View Dr. DePace’s professional profile
👉 View medical books by Dr. DePace

Click Here to Download this Blog Post – The Overactive Guard Dog: Understanding Mast Cell Activation Syndrome (MCAS) (Part 14)

By Dr. Nicholas L. DePace, M..D., F.A.C.C – Cardiologist specializing in autonomic dysfunction, Ehlers-Danlos syndrome and POTS.

• If you have hEDS or HSD, you might feel like you are allergic to the world. You aren’t just imagining it. Many people with connective tissue disorders also battle an immune system issue called Mast Cell Activation Syndrome (MCAS).

  What are Mast Cells?

  Think of mast cells as your body’s “guard dogs.” They live in almost every tissue and protect you from invaders like bacteria and viruses. When they spot a threat, the Sympathetic Nervous System (the gas pedal) tells them to attack by releasing chemicals like histamine.

  When the Guard Dog Goes Rogue

  In a healthy body, the Parasympathetic Nervous System (the brake pedal) keeps these cells calm. But because hEDS/HSD causes these nerves to glitch, the “brake” fails.

  The result? Your mast cells become confused. They start barking and biting at things that aren’t dangerous—like foods, smells, or temperature changes. This overreaction is MCAS.

  The Symptoms

  Because mast cells are everywhere, the symptoms can happen anywhere. It’s not just sneezing; it often looks like:

  • Skin:Hives, flushing, itching.
  • Gut:Nausea, vomiting, diarrhea (often misdiagnosed as IBS).
  • Heart:Racing heart, low blood pressure, fainting.
  • Lungs:Wheezing or throat tightness.
  • Brain:Brain fog and headaches.

  How is it Diagnosed?

  Doctors look for the “Rule of Three”:

  1. Clinical Signs:Symptoms in two or more body systems (e.g., skin and stomach).
  2. Lab Tests:High levels of specific chemicals (like Tryptase or histamine) in blood or urine. Note: You might also be tested for a genetic trait called HaT (Hereditary Alpha-Tryptasemia), which is common in EDS patients.
  3. Response to Treatment:You feel better when taking mast cell medications.

  The “Two-Door” Treatment Strategy

  Treating MCAS isn’t just about taking an allergy pill. Histamine has different ways of entering your cells, like different doors. To stop the reaction, you often need to lock both doors:

  • Block Door 1 (H1 Blockers):Common allergy meds like Zyrtec or Xyzal.
  • Block Door 2 (H2 Blockers):Meds often used for acid reflux, like Pepcid.

  If you only block one, the body just uses the other door, and you don’t get relief.

Where to Seek Expert Care?

It is important to seek out a clinician with expertise in EDS to make an accurate diagnosis and create a treatment plan. One of the nation’s leading centers is Franklin Cardiovascular Associates, under the direction of Nicholas DePace, MD, FACC. They are located in Sicklerville, New Jersey. franklincardiovascular.com, (856) 589-6034

About the Author

Nicholas L. DePace, MD, FACC is a board-certified cardiologist and Medical Director of Franklin Cardiovascular Associates. A graduate of the Mount Sinai School of Medicine, Dr. DePace has decades of clinical, academic, and research experience and has held faculty appointments as a Clinical Professor of Medicine, becoming one of the youngest full professors in Philadelphia at the time of his appointment.

Dr. DePace specializes in the diagnosis and treatment of autonomic nervous system dysfunction (dysautonomia), including POTS, autonomic dysfunction associated with Ehlers-Danlos syndrome (EDS), chronic fatigue, and anxiety-like conditions that are frequently misdiagnosed. He is nationally recognized for his work on parasympathetic and sympathetic (P&S) nervous system imbalance, a core mechanism underlying many complex chronic disorders.

In addition to treating patients from across the United States, Dr. DePace is a prolific clinical researcher and author of multiple nationally distributed medical textbooks published by Springer and W.W. Norton, focusing on autonomic dysfunction, mitochondrial disorders, cardiovascular disease, and mind–body medicine.

👉 View Dr. DePace’s professional profile
👉 View medical books by Dr. DePace